Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers.

@article{Lin2019FunctionsAT,
  title={Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers.},
  author={Chia-Hsueh Lin and Ying-chun Yeh and K. D. Yang},
  journal={Journal of the Formosan Medical Association = Taiwan yi zhi},
  year={2019}
}
  • Chia-Hsueh Lin, Ying-chun Yeh, K. D. Yang
  • Published 2019
  • Medicine
  • Journal of the Formosan Medical Association = Taiwan yi zhi
  • Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like lectins. All Siglecs have at least two domains including an extracellular domain with variable (V) and constant (C)-set immunoglobulin (Ig) regions, and a transmembrane domain. Some of the Siglecs (Siglec-2-12, -17, -E, -F and -G) with three domains including immunoreceptor tyrosine-based inhibitory motif associated with Src homology 2 (SH2) tyrosine phosphatases (SHP1/2) usually deliver an… CONTINUE READING
    5 Citations

    References

    SHOWING 1-10 OF 169 REFERENCES
    Siglecs in the immune system
    • 233
    • PDF
    Identification and Characterization of a Novel Siglec, Siglec-7, Expressed by Human Natural Killer Cells and Monocytes*
    • 211
    • PDF
    Siglecs as targets for therapy in immune-cell-mediated disease.
    • 155
    The interplay between Siglecs and sialylated pathogens.
    • 76
    • PDF