Functions and mechanisms of retrograde neurotrophin signalling

  title={Functions and mechanisms of retrograde neurotrophin signalling},
  author={Larry S Zweifel and Rejji Kuruvilla and David D Ginty},
  journal={Nature Reviews Neuroscience},
Neuronal connections are established and refined through a series of developmental programs that involve axon and dendrite specification, process growth, target innervation, cell death and synaptogenesis. Many of these developmental events are regulated by target-derived neurotrophins and their receptors, which signal retrogradely over long distances from distal-most axons to neuronal cell bodies. Recent work has established many of the cellular and molecular events that underlie retrograde… CONTINUE READING
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