Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system.

@article{Waterman2003FunctionsAE,
  title={Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system.},
  author={S. R. Waterman and David W. Holden},
  journal={Cellular microbiology},
  year={2003},
  volume={5 8},
  pages={501-11}
}
Salmonella enterica uses two functionally distinct type III secretion systems encoded on the pathogenicity islands SPI-1 and SPI-2 to transfer effector proteins into host cells. A major function of the SPI-1 secretion system is to enable bacterial invasion of epithelial cells and the principal role of SPI-2 is to facilitate the replication of intracellular bacteria within membrane-bound Salmonella-containing vacuoles (SCVs). Studies of mutant bacteria defective for SPI-2-dependent secretion… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS