Functions and development of red pulp macrophages

@article{Kurotaki2015FunctionsAD,
  title={Functions and development of red pulp macrophages},
  author={D. Kurotaki and T. Uede and T. Tamura},
  journal={Microbiology and Immunology},
  year={2015},
  volume={59}
}
Macrophages are extremely heterogeneous mononuclear phagocytes widely distributed throughout the body. They play unique roles in each organ where they reside. Among macrophage subsets, red pulp macrophages (RPMs) that localize in the splenic red pulp, are critical for maintenance of blood homeostasis by actively phagocytosing injured and senescent erythrocytes and blood‐borne particulates. Recent evidence indicates that RPMs are mainly generated during embryogenesis and are maintained during… Expand
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References

SHOWING 1-10 OF 66 REFERENCES
Role for SpiC in the development of red pulp macrophages and splenic iron homeostasis
Tissue macrophages comprise a heterogeneous group of cell types differing in location, surface markers and function. Red pulp macrophages are a distinct splenic subset involved in removing senescentExpand
CSF-1–Dependent Red Pulp Macrophages Regulate CD4 T Cell Responses
TLDR
Results suggested that splenic CSF-1–dependent F4/80hiMac-1low MΦs are a subpopulation of RPMs and regulate peripheral immune homeostasis. Expand
Origin and functions of tissue macrophages.
TLDR
The tools used for identifying the complex origin of tissue macrophages are defined and the relative contributions of tissue niche versus ontological origin to the regulation of macrophage functions during steady state and inflammation are discussed. Expand
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
TLDR
A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny. Expand
Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin.
TLDR
A high degree of functional specialization occurs among the mononuclear phagocytes of the skin when monocyte-derived DCs are continuously generated by extravasated Ly-6C(hi) monocytes. Expand
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
TLDR
Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis, and the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size. Expand
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
TLDR
It is found that the transcription factor Myb was required for development of HSCs and all CD11bhigh monocytes and macrophages, but was dispensable for yolk sac (YS)macrophages and for the development of YS-derived F4/80bright macrophage populations in several tissues. Expand
Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages
TLDR
It is reported that Spic regulated the development of F4/80(+)VCAM1(+) bone marrow macrophages (BMM) and thatSpic expression in BMM and RPM development was induced by heme, a metabolite of erythrocyte degradation. Expand
Development and heterogeneity of macrophages and their related cells through their differentiation pathways
TLDR
The distinct differentiation pathways of monocyte/macrophage, resident macrophages, other macrophage subpopulations, and Macrophage‐related cells are reviewed together with the heterogeneity of macrophAGE precursor cells. Expand
Development of Monocytes, Macrophages, and Dendritic Cells
TLDR
The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice. Expand
...
1
2
3
4
5
...