Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus.

@article{Schallreuter2006FunctioningMS,
  title={Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus.},
  author={Karin Uta Schallreuter and Katharina R{\"u}bsam and Bhaven Chavan and Carsten Zothner and Johanna M Gillbro and Jennifer D Spencer and John P. M. Wood},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={342 1},
  pages={145-52}
}
Oxidation of methionine residues by reactive oxygen (ROS) in protein structures leads to the formation of methionine sulfoxide which can consequently lead to a plethora of impaired functionality. The generation of methionine sulfoxide yields ultimately a diastereomeric mixture of the S and R sulfoxides. So far two distinct enzyme families have been identified. MSRA reduces methionine S-sulfoxide, while MSRB reduces the R-diastereomer. It has been shown that these enzymes are involved in… CONTINUE READING