Functionally enhanced brown adipose tissue in Ames dwarf mice.

@article{Darcy2017FunctionallyEB,
  title={Functionally enhanced brown adipose tissue in Ames dwarf mice.},
  author={Justin Darcy and Andrzej Bartke},
  journal={Adipocyte},
  year={2017},
  volume={6 1},
  pages={62-67}
}
Reduced insulin-like growth factor 1/insulin signaling (IIS) has been linked to extended longevity in species ranging from yeast to mammals. In mammals, this is exemplified in Ames dwarf (Prop1df/df) mice, which have a 40%-60% increase in longevity (males and females, respectively) due to their recessive Prop1 loss-of-function mutation that results in lack of growth hormone (GH), thyroid-stimulating hormone and prolactin. Our laboratory has previously shown that Ames dwarf mice have… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS