Functionally enhanced brown adipose tissue in Ames dwarf mice.

  title={Functionally enhanced brown adipose tissue in Ames dwarf mice.},
  author={Justin Darcy and Andrzej Bartke},
  volume={6 1},
Reduced insulin-like growth factor 1/insulin signaling (IIS) has been linked to extended longevity in species ranging from yeast to mammals. In mammals, this is exemplified in Ames dwarf (Prop1df/df) mice, which have a 40%-60% increase in longevity (males and females, respectively) due to their recessive Prop1 loss-of-function mutation that results in lack of growth hormone (GH), thyroid-stimulating hormone and prolactin. Our laboratory has previously shown that Ames dwarf mice have… CONTINUE READING
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