Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.

@article{Tyler2008FunctionallyDR,
  title={Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci.},
  author={David M. Tyler and Katsutomo Okamura and Wei-Jen Chung and Joshua W. Hagen and Eugene Berezikov and Gregory J Hannon and Eric C. Lai},
  journal={Genes & development},
  year={2008},
  volume={22 1},
  pages={26-36}
}
Many microRNA (miRNA) loci exhibit compelling hairpin structures on both sense and antisense strands; however, the possibility that a miRNA gene might produce functional species from its antisense strand has not been examined. We report here that antisense transcription of the Hox miRNA locus mir-iab-4 generates the novel pre-miRNA hairpin mir-iab-8, which… CONTINUE READING