Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.

@article{Tomso2005FunctionallyDP,
  title={Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.},
  author={Daniel J. Tomso and Alberto Inga and Daniel Vega Men{\'e}ndez and Gary S. Pittman and Michelle R. Campbell and Francesca Storici and Douglas A. Bell and Michael Resnick},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 18},
  pages={
          6431-6
        }
}
The p53 tumor suppressor protein is a master regulatory transcription factor that coordinates cellular responses to DNA damage and cellular stress. Besides mutations in p53, or in proteins involved in the p53 response pathway, genetic variation in promoter response elements (REs) of p53 target genes is expected to alter biological responses to stress. To identify SNPs in p53 REs that may modify p53-controlled gene expression, we developed an approach that combines a custom bioinformatics search… CONTINUE READING

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