Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase

@article{Mennella2005FunctionallyDK,
  title={Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase},
  author={Vito Mennella and Gregory C Rogers and Stephen L. Rogers and Daniel W Buster and Ronald D. Vale and David J. Sharp},
  journal={Nature Cell Biology},
  year={2005},
  volume={7},
  pages={235-245}
}
Regulation of microtubule polymerization and depolymerization is required for proper cell development. Here, we report that two proteins of the Drosophila melanogaster kinesin-13 family, KLP10A and KLP59C, cooperate to drive microtubule depolymerization in interphase cells. Analyses of microtubule dynamics in S2 cells depleted of these proteins indicate that both proteins stimulate depolymerization, but alter distinct parameters of dynamic instability; KLP10A stimulates catastrophe (a switch… CONTINUE READING

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