Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

@inproceedings{Mizoguchi2018FunctionallyDD,
  title={Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis},
  author={Fumitaka Mizoguchi and Kamil Slowikowski and Kevin S. Wei and Jennifer L. Marshall and Deepak A Rao and Sook Kyung Chang and Hung N. Nguyen and Erika H. Noss and Jason Dale Turner and Brandon E Earp and Philip Blazar and John V. Wright and Barry P. Simmons and Laura T Donlin and George D Kalliolias and Susan M Goodman and Vivian P Bykerk and Lionel B Ivashkiv and James A. Lederer and Nir Hacohen and Peter A Nigrovic and Andrew Filer and Christopher D Buckley and Soumya Raychaudhuri and Michael B Brenner},
  booktitle={Nature Communications},
  year={2018}
}
Fibroblasts regulate tissue homeostasis, coordinate inflammatory responses, and mediate tissue damage. In rheumatoid arthritis (RA), synovial fibroblasts maintain chronic inflammation which leads to joint destruction. Little is known about fibroblast heterogeneity or if aberrations in fibroblast subsets relate to pathology. Here, we show functional and transcriptional differences between fibroblast subsets from human synovial tissues using bulk transcriptomics of targeted subpopulations and… CONTINUE READING
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