Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation.

Abstract

In this report, we provide evidence that NGF and BDNF have functionally antagonistic actions on sympathetic neuron growth and target innervation, with NGF acting via TrkA to promote growth and BDNF via p75NTR to inhibit growth. Specifically, in cultured sympathetic neurons that themselves synthesize BDNF, exogenous BDNF inhibits and function-blocking BDNF… (More)

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@article{Kohn1999FunctionallyAI, title={Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation.}, author={Joachim Kohn and Raquel S. Aloyz and Jonathan Toma and Mary Haak-Frendscho and F. D. Miller}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={1999}, volume={19 13}, pages={5393-408} }