Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.

@article{Agndez2001FunctionallyAD,
  title={Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients.},
  author={Jos{\'e} A. G. Ag{\'u}ndez and Lori Gallardo and Mar{\`i}a Clara Ledesma and Luis Alberto Lozano and {\'A}lvaro Rodr{\'i}guez-Lescure and Josy Covan Pontes and Mar{\'i}a Cruz Iglesias-Moreno and J Poch and Jos{\'e} Mar{\'i}a Ladero and Julio Cesar Munoz Benitez},
  journal={Oncology},
  year={2001},
  volume={61 1},
  pages={59-63}
}
The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at increased risk. The occurrence of functionally active duplications of the CYP2D6 gene is a phenomenon that affects 3-8% of Caucasians and up to 30% in some ethnic groups. These… CONTINUE READING

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