Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.

@article{Pietras2015FunctionallyDS,
  title={Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.},
  author={Eric M. Pietras and Damien Reynaud and Yoon-A Kang and Daniel E. Carlin and Fernando J. Calero-Nieto and Andrew D. Leavitt and Joshua M. Stuart and Berthold G{\"o}ttgens and Emmanuelle Passegu{\'e}},
  journal={Cell stem cell},
  year={2015},
  volume={17 1},
  pages={35-46}
}
Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production. We find that all MPPs are produced in parallel by hematopoietic stem cells (HSCs), but with different kinetics and at variable levels depending on hematopoietic… CONTINUE READING
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