Functionalized thermoresponsive micelles self-assembled from biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA for tumor cell target.

@article{Cheng2008FunctionalizedTM,
  title={Functionalized thermoresponsive micelles self-assembled from biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA for tumor cell target.},
  author={Cheng Cheng and Hua Wei and Jing-Ling Zhu and Cong J Chang and Han Cheng and Cao Li and Si-Xue Cheng and Xianzheng Zhang and R Jin-Cong Zhuo},
  journal={Bioconjugate chemistry},
  year={2008},
  volume={19 6},
  pages={1194-201}
}
Novel micelles, comprising hydrophilic PEG shells, hydrophobic PMMA cores, and thermosensitive P(NIPAAm-co-HMAAm) segments were self-assembled from the biotin-PEG-b-P(NIPAAm-co-HMAAm)-b-PMMA triblock copolymer. The thermosensitive micelles exhibited superior stability and showed thermotriggered drug release behavior upon temperature alterations. The fluorescence spectroscopy and confocal microscopy studies confirmed that the self-assembled biotinylated micelles can be specifically and… CONTINUE READING
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