Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction.

  title={Functionalized nanoparticles provide early cardioprotection after acute myocardial infarction.},
  author={Ming-Yao Chang and Yu-Jen Yang and Chih-Han Chang and Alan C. L. Tang and W H Liao and Fong-Yu Cheng and Chen-Sheng Yeh and James J Lai and Patrick S. Stayton and Patrick Ching-Ho Hsieh},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={170 2},
Recent developments in nanotechnology have created considerable potential toward diagnosis and cancer therapy. In contrast, the use of nanotechnology in tissue repair or regeneration remains largely unexplored. We hypothesized that intramyocardial injection of insulin-like growth factor (IGF)-1-complexed poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (PLGA-IGF-1 NPs) increases IGF-1 retention, induces Akt phosphorylation, and provides early cardioprotection after acute myocardial… CONTINUE READING
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