Functionalized microcarriers improve T cell manufacturing by facilitating migratory memory T cell production and increasing CD4/CD8 ratio

@article{Dwarshuis2019FunctionalizedMI,
  title={Functionalized microcarriers improve T cell manufacturing by facilitating migratory memory T cell production and increasing CD4/CD8 ratio},
  author={Nathan Dwarshuis and H. Song and Anokhi Patel and Theresa Kotanchek and K. Roy},
  journal={bioRxiv},
  year={2019}
}
  • Nathan Dwarshuis, H. Song, +2 authors K. Roy
  • Published 2019
  • Chemistry, Biology
  • bioRxiv
  • Adoptive cell therapies (ACT) using chimeric antigen receptor (CAR) T cells have shown promise in treating cancer, but manufacturing large numbers of high quality cells remains challenging. Critically, current T cell expansion technologies only partially recapitulate the in vivo microenvironment found in the human lymph nodes. In these organs, T cells expand at high cell density with autocrine/paracrine signaling, as well as signals from the extracellular matrix (ECM). Here we describe a T cell… CONTINUE READING
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