Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.

Abstract

[reaction: see text] An efficient and operationally simple method for the synthesis of functionalized azaoxobicyclo[X.3.0]alkane amino acids has been devised. The key step is an intramolecular nitrone cycloaddition on 5-allyl- or 5-homoallylproline that was found to be completely regio- and stereoselective. 

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Cite this paper

@article{Manzoni2005FunctionalizedAA, title={Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition.}, author={Leonardo Manzoni and Daniela Arosio and Laura Belvisi and Antonio Bracci and Matteo Colombo and Donatella Invernizzi and Carlo Scolastico}, journal={The Journal of organic chemistry}, year={2005}, volume={70 10}, pages={4124-32} }