Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.

@article{Conley1987FunctionalizedDA,
  title={Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.},
  author={Judith D. Conley and Harold Kohn},
  journal={Journal of medicinal chemistry},
  year={1987},
  volume={30 3},
  pages={
          567-74
        }
}
Structural analogues of the potent known anticonvulsant agent N-acetyl-DL-alanine N-benzylamide (1a) have been prepared (16 examples). The pharmacological activities of these products were evaluated in the maximal electroshock seizure (MES), the subcutaneous pentylenetetrazole seizure threshold (sc Met), and the rotorod (Tox) tests. The median effective doses (ED50) and the median toxic doses (TD50) for the most active compounds by both intraperitoneal and oral administration are reported. The… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Similar Papers

Loading similar papers…