Functionalized Biomicroelectromechanical Systems Sensors for Force Response Study at Local Adhesion Sites of Single Living Cells on Substrates

@article{Saif2003FunctionalizedBS,
  title={Functionalized Biomicroelectromechanical Systems Sensors for Force Response Study at Local Adhesion Sites of Single Living Cells on Substrates},
  author={M. Taher A. Saif and Chad Randall Sager and Sean R Coyer},
  journal={Annals of Biomedical Engineering},
  year={2003},
  volume={31},
  pages={950-961}
}
We present a method of measuring force response of a single living cell, attached to a substrate, in situ, by a functionalized microelectromechanical systems sensor that applies local deformation on the cell. The sensor is a single crystal silicon microcantilever beam with prescribed shape and geometry, and is coated by a thin layer of fibronectin. It is brought in contact with a cell to form adhesion cites, and is then moved by a piezoactuator to deform the cell locally. The force is… CONTINUE READING

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