Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer.

@article{Sato2005FunctionalityOA,
  title={Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer.},
  author={Makoto Sato and Mai Johnson and Liqun Zhang and Sanjiv Sam Gambhir and Michael Carey and L. S.-Y. Wu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 10},
  pages={3743-9}
}
PURPOSE A highly augmented, prostate-specific two-step transcriptional amplification (TSTA) method was developed with the ultimate goal of delivering an effective and safe gene-based treatment to prostate cancer patients. Because very limited treatment options are available for recurrent hormone refractory prostate cancer (HRPC), it is imperative to assess whether the prostate-specific antigen (PSA) promoter-based TSTA gene therapy will be functional in HRPC. EXPERIMENTAL DESIGN We tested the… CONTINUE READING