Functionality of C-Reactive Protein for Atheroprotection

  title={Functionality of C-Reactive Protein for Atheroprotection},
  author={Sanjay K. Singh and Alok Agrawal},
  journal={Frontiers in Immunology},
C-reactive protein (CRP) is a pentameric molecule made up of identical monomers. CRP can be seen in three different forms: native pentameric CRP (native CRP), non-native pentameric CRP (non-native CRP), and monomeric CRP (mCRP). Both native and non-native CRP execute ligand-recognition functions for host defense. The fate of any pentameric CRP after binding to a ligand is dissociation into ligand-bound mCRP. If ligand-bound mCRP is proinflammatory, like free mCRP has been shown to be in vitro… Expand
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