Functionality and the evolution of marginal stability in proteins: Inferences from lattice simulations

@inproceedings{Williams2006FunctionalityAT,
  title={Functionality and the evolution of marginal stability in proteins: Inferences from lattice simulations},
  author={Paul D. Williams and David D. Pollock and Richard A. Goldstein},
  booktitle={Evolutionary bioinformatics online},
  year={2006}
}
It has been known for some time that many proteins are marginally stable. This has inspired several explanations. Having noted that the functionality of many enzymes is correlated with subunit motion, flexibility, or general disorder, some have suggested that marginally stable proteins should have an evolutionary advantage over proteins of differing stability. Others have suggested that stability and functionality are contradictory qualities, and that selection for both criteria results in… CONTINUE READING