Functionalisation of tetraalkylsilanes derived from CH activation; towards annulations of diterpenoids

@inproceedings{Harris2000FunctionalisationOT,
  title={Functionalisation of tetraalkylsilanes derived from CH activation; towards annulations of diterpenoids},
  author={Paul William Harris and Clifton E. F. Rickard and Paul D. Woodgate},
  year={2000}
}
Abstract Vinyl trialkylsilanes are efficient substrates for use in the ortho alkylation of aromatic ketones catalysed by zerovalent ruthenium complexes, giving, e.g. (2-trimethylsilylethyl)acetophenones. Methods for the selective desilylation–functionalisation of such tetraalkylsilanes are investigated. Some diterpenoid tetraalkylsilanes derived from the ruthenium-catalysed insertion of vinyltrimethylsilane have been functionalised by benzylic bromination of an ArCH 2 CH 2 SiMe 3 fragment with… CONTINUE READING