Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy.

@article{Mil2007FunctionalVO,
  title={Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy.},
  author={Saskia W. C. van Mil and Alexandra Milona and Peter H. Dixon and Roman Mullenbach and Victoria L Geenes and Jenny Chambers and V. U. Shevchuk and Gudrun E Moore and Frank Lammert and Anna Glantz and L A Mattsson and J. Whittaker and Malcolm G. Parker and Roger White and Catherine Williamson},
  journal={Gastroenterology},
  year={2007},
  volume={133 2},
  pages={
          507-16
        }
}
BACKGROUND AND AIMS Intrahepatic cholestasis of pregnancy (ICP) is characterized by liver impairment, pruritus, and elevated maternal serum bile acids. It can cause premature delivery and intrauterine death. Bile acid synthesis, metabolism, and transport are regulated by the bile acid sensor FXR, and we hypothesized that genetic variation in FXR confers susceptibility to ICP. METHODS The coding regions and intron/exon boundaries of FXR were sequenced in 92 British ICP cases of mixed ethnicity… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 99 CITATIONS, ESTIMATED 32% COVERAGE

Genetic disorders of nuclear receptors.

  • The Journal of clinical investigation
  • 2017
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

New Insights on Intrahepatic Cholestasis of Pregnancy.

  • Clinics in liver disease
  • 2016
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

New molecular insights into the mechanisms of cholestasis.

  • Journal of hepatology
  • 2009
VIEW 16 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Enfermedades hepáticas durante el embarazo

Pablo Bellot García y José María Palazón Azorín
  • 2019

FILTER CITATIONS BY YEAR

2008
2019

CITATION STATISTICS

  • 8 Highly Influenced Citations