Functional validation of the carbon dioxide receptor genes in Aedes aegypti mosquitoes using RNA interference.

@article{Erdelyan2012FunctionalVO,
  title={Functional validation of the carbon dioxide receptor genes in Aedes aegypti mosquitoes using RNA interference.},
  author={Cassidy NG Erdelyan and Thomas H Mahood and Tarif Bader and Steven Whyard},
  journal={Insect molecular biology},
  year={2012},
  volume={21 1},
  pages={119-27}
}
Carbon dioxide (CO(2)) is an important long-range chemosensory cue used by blood-feeding female mosquitoes to find their hosts. The CO(2) receptor in Drosophila melanogaster was previously determined to be a heterodimer comprised of two gustatory receptor (Gr) proteins, DmGr21a and DmGr63a. In the mosquito Aedes aegypti, two putative orthologous genes, AaGr1 and AaGr3, were identified in the genome database, along with an apparent paralogue of AaGr1, AaGr2. In this study, RNA interference (RNAi… CONTINUE READING
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