Functional uroselectivity.

  title={Functional uroselectivity.},
  author={Dr. Roy. J. Martin and Itzchak Angel and Sonia Arbilla},
  journal={European urology},
  volume={33 Suppl 2},
Alpha1-adrenoceptors mediating sympathetic tone to smooth muscle cells are located within the prostatic tissue, bladder base and in the proximal urethra, but are also widely distributed within a large number of tissues, especially the vascular beds and the central nervous system. Compounds clinically used in the symptomatic treatment of benign prostatic hyperplasia must therefore exhibit functional uroselectivity. This means that they should preferentially act on the lower urinary tract rather… CONTINUE READING

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