Functional uncoupling of hemodynamic from neuronal response by inhibition of neuronal nitric oxide synthase.

@article{Stefanovic2007FunctionalUO,
  title={Functional uncoupling of hemodynamic from neuronal response by inhibition of neuronal nitric oxide synthase.},
  author={Bojana Stefanovic and Wolfram Schwindt and Mathias Hoehn and Afonso C. Silva},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2007},
  volume={27 4},
  pages={
          741-54
        }
}
The cerebrovascular coupling under neuronal nitric oxide synthase (nNOS) inhibition was investigated in alpha-chloralose anesthetized rats. Cerebral blood flow (CBF), cerebral blood volume (CBV), and blood oxygenation level dependent (BOLD) responses to electrical stimulation of the forepaw were measured before and after an intraperitoneal bolus of 7-nitroindazole (7-NI), an in vivo inhibitor of the neuronal isoform of nitric oxide synthase. Neuronal activity was measured by recording… CONTINUE READING
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