Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation.

@article{Butler2008FunctionalTE,
  title={Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation.},
  author={David Butler and Natalia Juncosa-Melvin and Gregory P. Boivin and Marc T. Galloway and Jason T. Shearn and Cynthia Gooch and Hani A Awad},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2008},
  volume={26 1},
  pages={1-9}
}
Over the past 8 years, our group has been continuously improving tendon repair using a functional tissue engineering (FTE) paradigm. This paradigm was motivated by inconsistent clinical results after tendon repair and reconstruction, and the modest biomechanical improvements we observed after repair of rabbit central patellar tendon defects using mesenchymal stem cell-gel-suture constructs. Although possessing a significantly higher stiffness and failure force than for natural healing, these… CONTINUE READING

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