Functional thrombomodulin expression on epithelial skin tumours as a differentiation marker for suprabasal keratinocytes.

@article{Mizutani1996FunctionalTE,
  title={Functional thrombomodulin expression on epithelial skin tumours as a differentiation marker for suprabasal keratinocytes.},
  author={Hitoshi Mizutani and S Ohyanagi and Tatsuya Hayashi and Richard W. Groves and Kotaro Suzuki and Michio Shimizu},
  journal={The British journal of dermatology},
  year={1996},
  volume={135 2},
  pages={187-93}
}
In normal human skin,, immunoreactive thrombomodulin (TM) is expressed in a strict differentiation related pattern, solely in suprabasal spinous layer keratinocytes. To evaluate the potential application of TM as a differentiation marker for keratinocyte-derived skin tumours, we have studied immunohistopathological, biochemical and functional TM activities in various skin tumours. Immunoreactive, full sized and enzymatically active TM was expressed in keratinocyte-derived skin tumours (squamous… CONTINUE READING

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