Functional surfaces of the human immunodeficiency virus type 1 capsid protein.

@article{Schwedler2003FunctionalSO,
  title={Functional surfaces of the human immunodeficiency virus type 1 capsid protein.},
  author={Uta K von Schwedler and Kirsten M. Stray and Jennifer E. Garrus and Wesley I. Sundquist},
  journal={Journal of virology},
  year={2003},
  volume={77 9},
  pages={5439-50}
}
The human immunodeficiency virus type 1 initially assembles and buds as an immature particle that is organized by the viral Gag polyprotein. Gag is then proteolyzed to produce the smaller capsid protein CA, which forms the central conical capsid that surrounds the RNA genome in the mature, infectious virus. To define CA surfaces that function at different stages of the viral life cycle, a total of 48 different alanine-scanning surface mutations in CA were tested for their effects on Gag protein… CONTINUE READING
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