Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection.

@article{SmykPearson2008FunctionalSB,
  title={Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection.},
  author={Susan Smyk-Pearson and Lucy Golden-Mason and Jared Klarquist and James R. Burton and Ian A. Tester and Chia Ching Wang and Nicole E. Culbertson and Arthur A. Vandenbark and Hugo R Rosen},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={197 1},
  pages={46-57}
}
BACKGROUND Infection with hepatitis C virus (HCV) is characterized by impairment of viral effector T cell responses and a high propensity for viral persistence. Previous studies have demonstrated that chronic HCV infection is associated with an increased frequency of regulatory T (T(reg)) cells, compared with that in persons whose infection resolved and in healthy persons. However, all patients in prior analyses had exposures in the distant past, precluding the ability to determine whether T… CONTINUE READING

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