Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.

@article{Lu2012FunctionalSO,
  title={Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.},
  author={Lingeng Lu and Dionyssios Katsaros and Susan Taylor Mayne and Harvey A. Risch and Chiara Benedetto and Emilie Marion Canuto and Herbert Yu},
  journal={Carcinogenesis},
  year={2012},
  volume={33 11},
  pages={2119-25}
}
Several single-nucleotide polymorphisms (SNPs) of the stem cell-associated gene lin-28B have been identified in association with ovarian cancer and ovarian cancer-related risk factors. However, whether these SNPs are functional or might be potential biomarkers for ovarian cancer prognosis remains unknown. The purposes of this study were to investigate the functional relevance of the identified lin-28B SNPs, as well as the associations of genotype and phenotype with epithelial ovarian cancer… CONTINUE READING
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