Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma.

@article{Yau2006FunctionalSO,
  title={Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma.},
  author={Wing Lung Yau and Hong Lok Lung and Eugene R. Zabarovsky and M. I. Lerman and Jonathan Shun-Tong Sham and Daniel Tsin-Tien Chua and Sai Wah Tsao and Eric John Stanbridge and Maria Li Lung},
  journal={International journal of cancer},
  year={2006},
  volume={119 12},
  pages={2821-6}
}
Chromosome 3p plays an important role in tumorigenesis in many cancers, including nasopharyngeal carcinoma (NPC). We have previously shown chromosome 3p can suppress tumor growth in vivo by using the monochromosome transfer approach, which indicated the chromosome 3p21.3 region was critical for tumor suppression. BLU/ZMYND10 is one of the candidate tumor suppressor genes mapping in the 3p21.3 critical region and is a candidate TSG for NPC. By quantitative RT-PCR, it is frequently downregulated… CONTINUE READING

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