• Corpus ID: 25985764

Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).

  title={Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).},
  author={Pancras C Wong and S D Hart and Alverna M. Zaspel and Andrew T. Chiu and Robert John Ardecky and R. D. Smith and Pieter B.M.W.M. Timmermans},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={255 2},
  • P. WongS. Hart P. Timmermans
  • Published 1 November 1990
  • Biology, Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
DuP 753 and PD123177 are two nonpeptide angiotensin II (AII)-specific ligands, which show high affinities for two respective and distinct subtypes of AII binding sites, i.e., AII-1 and AII-2 sites, respectively, in the rat adrenal gland, brain and uterus. The objective of this study is to identify the functions of these subtype binding sites in the adrenal, sympathetic ganglia, brain and vascular smooth muscle. In conscious rats, DuP 753 at 1, 3 and 10 mg/kg i.v. but not PD123177 at 30 and 100… 

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DuP 753, a nonpeptide angiotensin II-1 receptor antagonist, alters dopaminergic function in rat striatum

The results in vitro suggest that acutely the agonist increasesDA neurotransmission and the antagonist decreases DA neurotransmission, and chronic in vivo administration of DuP 753 appears to result in a compensatory response of the dopaminergic system in striatum.