• Corpus ID: 25985764

Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).

  title={Functional studies of nonpeptide angiotensin II receptor subtype-specific ligands: DuP 753 (AII-1) and PD123177 (AII-2).},
  author={Pancras C Wong and S D Hart and Alverna M. Zaspel and Andrew T. Chiu and Robert John Ardecky and Ronald D. Smith and Pieter B.M.W.M. Timmermans},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={255 2},
DuP 753 and PD123177 are two nonpeptide angiotensin II (AII)-specific ligands, which show high affinities for two respective and distinct subtypes of AII binding sites, i.e., AII-1 and AII-2 sites, respectively, in the rat adrenal gland, brain and uterus. The objective of this study is to identify the functions of these subtype binding sites in the adrenal, sympathetic ganglia, brain and vascular smooth muscle. In conscious rats, DuP 753 at 1, 3 and 10 mg/kg i.v. but not PD123177 at 30 and 100… 
Nonpeptide angiotensin II receptor antagonists. Studies with DuP 753 and EXP3174 in dogs.
Results suggest that the AT1 receptor mediates the pressor and renal effects of AII in dogs, and that the acute transient hypotensive effect of DuP 753 in normal-renin conscious dogs is probably unrelated to AII antagonism.
Effect of a nonpeptide angiotensin II receptor antagonist, DuP 753, on angiotensin-related water intake in rats
The results suggest that the drinking responses to angiotensin II-1 (AII) receptor blocker, DuP 753, are mediated by AII-1 receptors, and suggest that either AIII acts via the Aii-1 receptor or that DuP 653 competes at an AIII-sensitive receptor.
Molecular characterization of angiotensin II type II receptors in rat pheochromocytoma cells
PC12W cells express a homogeneous population of AT2 binding sites which differ significantly from AT1 receptors in signal transduction and molecular structure, indicating that AT2 sites may act via potentially novel, biochemical pathways or, alternatively, be vestigial receptors.
Overlapping distribution of receptors for atrial natriuretic peptide and angiotensin II in the kidney and the adrenal gland of the freshwater turtle, Amyda japonica.
The results suggest that biological and clearance ANP receptor-like subtypes coexist in both tissues, and the predominant ANG II receptor subtype in these tissues is the AT1-like receptor.
Characterization of a new angiotensin antagonist selective for angiotensin-(1–7): Evidence that the actions of angiotensin-(1–7) are mediated by specific angiotensin receptors
Results show that A-779 is a potent and selective antagonist for Ang-(1-7), and data indicate that specific angiotensin receptors mediate the central and peripheral actions of Ang-( 1-7).
Effect of an angiotensin II receptor antagonist, CV-11974, and its prodrug, TCV-116, on production of aldosterone.
In spontaneously hypertensive rats, TCV-116 at daily p.o. doses of 0.1, 1 and 10 mg/kg for 2 weeks caused a dose-dependent reduction of blood pressure and plasma aldosterone concentration without affecting plasma corticosterone, and inhibited the induction of ald testosterone production by not only exogenous but also endogenous angiotensin II.
Characterization of angiotensin II antagonism displayed by Ib, a novel nonpeptide angiotensin AT(1) receptor antagonist.
I is a potent angiotensin AT(1) selective receptor antagonist with a mode of insurmountable antagonism and produced a dose-dependent antihypertensive effects in spontaneously hypertensive rats and renal hypertensive Rats.
Nonpeptide Angiotensin II Receptor Antagonist: Losartan
Publisher Summary Losartan is the prototype of a new class of orally active, nonpeptide angiotensin II (AII) receptor antagonists. Losartan inhibits specifically the renin-angiotensin system (RAS)
Defining Angiotensin Receptor Subtypes
Historically, suggestions of multiple receptor subtypes for angiotensin II (ANG II) were based on a number of experimental observations involving the differences in the concentration—response