Functional studies in 3 T 3 L 1 cells support a role for SNARE proteins in insulin stimulation of GLUT 4 translocation

@inproceedings{Macaulay1997FunctionalSI,
  title={Functional studies in 3 T 3 L 1 cells support a role for SNARE proteins in insulin stimulation of GLUT 4 translocation},
  author={Symington Macaulay and Dean R. Hewish and Keith Harry. Gough and Violet Stoichevska and Susan F. Macpherson and Mittur N. Jagadish and Colin W. Ward},
  year={1997}
}
Insulin stimulation of glucose transport in the major insulinresponsive tissues results predominantly from the translocation to the cell surface of a particular glucose transporter isoform, GLUT4, residing normally under basal conditions in intracellular vesicular structures. Recent studies have identified the presence of vesicle-associated membrane protein (VAMP) 2, a protein involved in vesicular trafficking in secretory cell types, in the vesicles of insulin-sensitive cells that contain… CONTINUE READING

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Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells.

  • American journal of physiology. Cell physiology
  • 2000
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