Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion.

  title={Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion.},
  author={C. Netter and G. Weber and H. Benecke and M. Wahl},
  volume={15 7},
  • C. Netter, G. Weber, +1 author M. Wahl
  • Published 2009
  • Biology, Medicine
  • RNA
  • RNA recognition motifs (RRMs) constitute versatile macromolecular interaction platforms. They are found in many components of spliceosomes, in which they mediate RNA and protein interactions by diverse molecular strategies. The human U11/U12-65K protein of the minor spliceosome employs a C-terminal RRM to bind hairpin III of the U12 small nuclear RNA (snRNA). This interaction comprises one side of a molecular bridge between the U11 and U12 small nuclear ribonucleoprotein particles (snRNPs) and… CONTINUE READING
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