Functional specificity of the mitochondrial DnaJ protein, Mdj1p, in Saccharomyces cerevisiae

@article{Lisse2000FunctionalSO,
  title={Functional specificity of the mitochondrial DnaJ protein, Mdj1p, in Saccharomyces cerevisiae},
  author={Thomas Lisse and Elisabeth Schwarz},
  journal={Molecular and General Genetics MGG},
  year={2000},
  volume={263},
  pages={527-534}
}
Inactivation of the gene for the mitochondrial DnaJ homolog, Mdj1p, in Saccharomyces cerevisiae results in temperature sensitivity and the loss of respiratory activity; the latter phenotype has been attributed to the loss of mitochondrial DNA. To investigate the functional specificity of Mdj1p, non-mitochondrial DnaJ proteins were targeted to mitochondria and tested for their ability to substitute for Mdj1p. The tested DnaJ proteins were able to complement the two Mdj1p-linked phenotypes, i.e… CONTINUE READING