Functional specificity of ras isoforms: so similar but so different.

  title={Functional specificity of ras isoforms: so similar but so different.},
  author={Esther Castellano and Eugenio Santos},
  journal={Genes & cancer},
  volume={2 3},
H-ras, N-ras, and K-ras are canonical ras gene family members frequently activated by point mutation in human cancers and coding for 4 different, highly related protein isoforms (H-Ras, N-Ras, K-Ras4A, and K-Ras4B). Their expression is nearly ubiquitous and broadly conserved across eukaryotic species, although there are quantitative and qualitative differences of expression depending on the tissue and/or developmental stage under consideration. Extensive functional studies have determined… CONTINUE READING

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