Functional specialization of the glycosylphosphatidylinositol membrane anchor.

@article{Anderson1994FunctionalSO,
  title={Functional specialization of the glycosylphosphatidylinositol membrane anchor.},
  author={Richard G. W. Anderson},
  journal={Seminars in immunology},
  year={1994},
  volume={6 2},
  pages={89-95}
}
The discovery of GPI-anchored membrane proteins presented a conundrum for membrane biologists. What could the special purpose be for this type of membrane anchor and why couldn't a transmembrane anchor do the same job? Recent information from several different sources is beginning to provide answers to these questions. In this review, evidence is presented that GPI-anchored membrane proteins are uniquely adapted for delivering to the cell both nutrient and signaling molecules or ions using two… CONTINUE READING