Functional specialization and topographic segregation of hippocampal astrocytes.

  title={Functional specialization and topographic segregation of hippocampal astrocytes.},
  author={Raimondo D'Ambrosio and Juergen Wenzel and Philip A. Schwartzkroin and Guy McKhann and Damir Janigro},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={18 12},
Astrocytes have been suggested to play several roles in the complex control of brain microenvironment. However, they have been generally considered to constitute a homogeneous population of cells. Here we show that at least three electrophysiologically distinct types of astrocytes can be found in the mature hippocampus. These subpopulations of glia were characterized by expression of different ion currents. In astrocytes exposed to elevated K+, Cs+ prevented influx of K+ only in cells with… CONTINUE READING
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