Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients

@article{Hizawa2008FunctionalSN,
  title={Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients},
  author={N. Hizawa and H. Makita and Y. Nasuhara and M. Hasegawa and K. Nagai and Y. Ito and T. Betsuyaku and S. Konno and M. Nishimura},
  journal={European Respiratory Journal},
  year={2008},
  volume={32},
  pages={372 - 378}
}
  • N. Hizawa, H. Makita, +6 authors M. Nishimura
  • Published 2008
  • Medicine
  • European Respiratory Journal
  • It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age ≥40 yrs. The clinical diagnosis of chronic obstructive pulmonary disease (COPD) includes emphysema and small airway disease, and upregulation of CCL5 has been described in the… CONTINUE READING
    26 Citations
    Association of the CAT-262C>T polymorphism with asthma in smokers and the nonemphysematous phenotype of chronic obstructive pulmonary disease.
    • N. Taniguchi, S. Konno, +7 authors M. Nishimura
    • Medicine
    • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
    • 2014
    • 8
    Association of ET-1 gene polymorphisms with COPD phenotypes in a Caucasian population.
    • 5
    • PDF
    Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in northern Spain.
    • 26
    Asthma Phenotypes in Japanese Adults - Their Associations with the CCL5 ADRB2 Genotypes.
    • Y. Kaneko, H. Masuko, +8 authors N. Hizawa
    • Medicine
    • Allergology international : official journal of the Japanese Society of Allergology
    • 2013
    • 28
    Gene polymorphisms and chronic obstructive pulmonary disease
    • 20
    Pathogenic triad in COPD: oxidative stress, protease–antiprotease imbalance, and inflammation
    • 187
    • PDF
    Updates on the COPD gene list
    • Y. Bossé
    • Medicine
    • International journal of chronic obstructive pulmonary disease
    • 2012
    • 78
    • PDF
    Immune-related gene polymorphisms in pulmonary diseases.
    • 6
    Genetic analysis of asthma exacerbations.
    • W. Anderson, Beena T. Koshy, +4 authors H. Ortega
    • Medicine
    • Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
    • 2013
    • 3
    Genetic backgrounds of asthma and COPD.
    • N. Hizawa
    • Biology, Medicine
    • Allergology international : official journal of the Japanese Society of Allergology
    • 2009
    • 17

    References

    SHOWING 1-10 OF 31 REFERENCES
    The RANTES promoter polymorphism: a genetic risk factor for near-fatal asthma in Chinese children.
    • 74
    Atopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES1
    • 280
    • PDF
    Exacerbations of Bronchitis: bronchial eosinophilia and gene expression for interleukin-4, interleukin-5, and eosinophil chemoattractants.
    • 210
    Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease.
    • 923
    Amplification of inflammation in emphysema and its association with latent adenoviral infection.
    • 501