Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients.

@article{Hizawa2008FunctionalSN,
  title={Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients.},
  author={Nobuyuki Hizawa and Hironi Makita and Yasuyuki Nasuhara and Masaru Hasegawa and Katsura Nagai and Yoko Ito and Tomoko Betsuyaku and Satoshi Konno and Masaharu Nishimura},
  journal={The European respiratory journal},
  year={2008},
  volume={32 2},
  pages={
          372-8
        }
}
It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs. The clinical diagnosis of chronic obstructive pulmonary disease (COPD) includes emphysema and small airway disease, and upregulation of CCL5 has been described in… CONTINUE READING

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