Functional silencing is initiated and maintained in immature anti-insulin B cells.

@article{Henry2009FunctionalSI,
  title={Functional silencing is initiated and maintained in immature anti-insulin B cells.},
  author={Rachel Anne Henry and Carlos A. Acevedo-Su{\'a}rez and James W. Thomas},
  journal={Journal of immunology},
  year={2009},
  volume={182 6},
  pages={
          3432-9
        }
}
Mechanisms of B cell tolerance act during development in the bone marrow and periphery to eliminate or restrict autoreactive clones to prevent autoimmune disease. B cells in the spleens of mice that harbor anti-insulin BCR transgenes (125Tg) are maintained in a functionally silenced or anergic state by endogenous hormone, but it is not clear when and where anergy is induced. An in vitro bone marrow culture system was therefore used to probe whether small protein hormones, a critical class of… CONTINUE READING
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