Functional significance of the pentose phosphate pathway and glutathione reductase in the antioxidant defenses of human sperm.

@article{Williams2004FunctionalSO,
  title={Functional significance of the pentose phosphate pathway and glutathione reductase in the antioxidant defenses of human sperm.},
  author={Andrew Colin Williams and W. Chris L. Ford},
  journal={Biology of reproduction},
  year={2004},
  volume={71 4},
  pages={1309-16}
}
Glutathione peroxidase is one of the principal antioxidant defense enzymes in human spermatozoa, but it requires oxidized glutathione to be reduced by glutathione reductase using NADPH generated in the pentose phosphate pathway. We investigated whether flux through the pentose phosphate pathway would increase in response to oxidative stress and whether glutathione reductase was required to protect sperm from oxidative damage. Isotopic measurements of the pentose phosphate pathway and glycolytic… CONTINUE READING

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