Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.

@article{Davis2003FunctionalSO,
  title={Functional significance of protein kinase A activation by endothelin-1 and ATP: negative regulation of SRF-dependent gene expression by PKA.},
  author={Amanda Davis and Kyle Hogarth and Darren J Fernandes and Julian Solway and Jiaxin Niu and Vladimir Kolenko and Darren D Browning and Joseph M. Miano and Sergei N. Orlov and Nickolai O. Dulin},
  journal={Cellular signalling},
  year={2003},
  volume={15 6},
  pages={597-604}
}
Endothelin-1 (ET1) and ATP stimulate contraction and hypertrophy of vascular smooth muscle cells (VSMC) by activating diverse signalling pathways. In this study, we show that in VSMC, ET1 and ATP stimulate transient and sustained activation of protein kinase A (PKA), respectively. Using a dominant negative PKA mutant (PKA-DN), we examined the functional significance of PKA activation in the signalling of ET1 and ATP. Overexpression of PKA-DN did not alter the ET1- or ATP-induced phosphorylation… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…