Functional significance of loops in the receptor binding domain of Bacillus thuringiensis CryIIIA delta-endotoxin.

@article{Wu1996FunctionalSO,
  title={Functional significance of loops in the receptor binding domain of Bacillus thuringiensis CryIIIA delta-endotoxin.},
  author={Sandra Jones Wu and Donald Harry Dean},
  journal={Journal of molecular biology},
  year={1996},
  volume={255 4},
  pages={
          628-40
        }
}
Analysis of the three surface loops in domain II of Bacillus thuringiensis CryIIIA delta-endotoxin has been carried out to assess their role in receptor binding and toxicity. Site-directed mutagenesis was used to convert loop residues to alanine and the mutant proteins were analyzed for structural stability, toxicity to beetle larvae (Tenebrio molitor), binding to receptors on T. molitor brush border membrane vesicles (Tm-BBMV) and insertion into BBMV, as measured by irreversible membrane… CONTINUE READING
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