Functional significance of cytochrome P450 1B1 in endometrial carcinogenesis.

Abstract

Cytochrome P450 1B1 (CYP1B1) catalyzes estrogen hydroxylation and activation of potential carcinogens. Here we explored the role of CYP1B1 in endometrial carcinogenesis. Immunohistochemical staining of endometrial carcinomas showed that CYP1B1 is up-regulated in endometrial cancers. To understand the functional significance of CYP1B1 up-regulation in… (More)
DOI: 10.1158/0008-5472.CAN-09-1691

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