Functional significance of cleavable signal peptides of G protein-coupled receptors.

@article{Schlein2012FunctionalSO,
  title={Functional significance of cleavable signal peptides of G protein-coupled receptors.},
  author={Ralf Sch{\"u}lein and Carolin Westendorf and Gerd Krause and W. Philip Rosenthal},
  journal={European journal of cell biology},
  year={2012},
  volume={91 4},
  pages={
          294-9
        }
}
About 5-10% of the G protein-coupled receptors (GPCRs) contain N-terminal signal peptides that are cleaved off by the signal peptidases of the endoplasmic reticulum (ER) during the translocon-mediated receptor insertion into the ER membrane. The reason as to why only a subset of the GPCRs requires these additional signal peptides was addressed in the past decade only by a limited number of studies. Recent progress suggests that signal peptides of GPCRs do not only serve the classical ER… CONTINUE READING
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