Functional significance of cell volume regulatory mechanisms.

  title={Functional significance of cell volume regulatory mechanisms.},
  author={Florian Lang and Gillian L. Busch and Markus Ritter and Harold V{\"o}lkl and Siegfried Waldegger and Erich Gulbins and Dieter H{\"a}ussinger},
  journal={Physiological reviews},
  volume={78 1},
To survive, cells have to avoid excessive alterations of cell volume that jeopardize structural integrity and constancy of intracellular milieu. The function of cellular proteins seems specifically sensitive to dilution and concentration, determining the extent of macromolecular crowding. Even at constant extracellular osmolarity, volume constancy of any mammalian cell is permanently challenged by transport of osmotically active substances across the cell membrane and formation or disappearance… 

Figures and Tables from this paper

Mechanisms Sensing and Modulating Signals Arising From Cell Swelling

The intracellular mechanisms underlying the sensing of cell volume perturbations and the activation of volume compensatory processes, commonly summarized as regulatory volume decrease (RVD), are revealed.

Cell Volume and Gene Expression

The expression of cell volume sensitive genes may be triggered not only by alterations of extracellular osmolarity but as well by other factors modifying cell volume, and represent an important novel mechanism comparable to a second or third messenger triggering certain patterns of gene expression.

Ion channels and transporters involved in cell volume regulation and sensor mechanisms

  • Y. Okada
  • Biology
    Cell Biochemistry and Biophysics
  • 2007
In cell volume regulation mechanism, several “volume sensors” are thought to be involved and a volume-sensitive Cl− channel has lately attracted considerable attention in this regard.

Cell volume and monovalent ion transporters: their role in cell death machinery triggering and progression.

In conclusion, inhibition of Na(+)-K( +)-ATPase by cardiotonic steroids (CTS) rescues rat vascular smooth muscle cells from apoptosis via a novel Na(+)i-K(+i-mediated, Ca(2%)i-independent mechanism of excitation-transcription coupling, and monovalent ion transporters play diverse roles in the cell death machinery.

Cell Volume in the Regulation of Cell Proliferation and Apoptotic Cell Death

Little is known about the interplay of cell volume regulatory mechanisms and the cellular machinery leading to mitosis or death of the cell and considerable further experimental effort is required in this exciting area of cell physiology.

Physiology of cell volume regulation in vertebrates.

Current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species are reviewed.

Physiological significance of volume-regulatory transporters.

  • W. C. O'Neill
  • Biology
    American journal of physiology. Cell physiology
  • 1999
Volume-regulatory transporters are closely linked to cell growth and metabolism, producing requisite changes in cell volume that may also signal subsequent growth and metabolic events, and have important roles in mammalian physiology.

Cell volume regulation: physiology and pathophysiology

Recent major developments in the field are summarized, and significant progress has been made with respect to the nature of the sensors, transducers and effectors that convert a change in cell volume into a physiological response.

Cell volume regulation: osmolytes, osmolyte transport, and signal transduction.

The information available indicates the existence of intricate spatial and temporal networks that control cell volume and that the authors are just beginning to be able to investigate and to understand.



The Diversity of Volume Regulatory Mechanisms

The diversity of cellVolume regulatory mechanisms allows the cells to defend the constancy of cell volume against a myriad of challenges with relatively little impairment of cellular function.

The role of cellular hydration in the regulation of cell function.

Cell volume homeostasis does not simply mean volume constancy, but rather the integration of events which allow cell hydration to play its physiological role as a regulator of cell function (for reviews see [1–4]).


It seems that the volume regulatory mechanisms utilized by all cells may be more similar than currently thought, differing in relative con tributions of the two solute types rather than kind of solute utilized.

Cell Volume and Hepatic Metabolism

Cell volume homeostasis does not mean the absolute constancy of cell volume, but rather the integration of events allowing cell volume changes to play a regulatory role in cellular function.

Ionic mechanisms of cell volume regulation in leukocytes.

The preservation of near-normal size under such a variety of conditions suggests that the cells are able to sense the presence of volume­ sensitive ion transport pathways and to compensate for departure from an optimal, physiologic state.

Cell volume regulation

Cell volume regulatory mechanisms, signalling, osmolytes and cell heterogeneity volume regulation and "cross-talk" in sodium-absorbing epithelial cells, and the pathophysiology of abnormal cell volume in human red cells swelling-activated release of excitatory amino acids in the brain are studied.

Problems in the understanding of cell volume regulation.

It is argued that regulation of cell volume should not be seen in isolation but as part of the process, cell homeostasis, by which cells attempt to minimise changes in composition when faced with perturbations in their environment.

Involvement of calcium and cytoskeleton in gallbladder epithelial cell volume regulation.

Results indicate that RVD depends on calcium, calmodulin, and an intact microfilament network, whereas RVI is independent of these factors.

Molecular basis of osmotic regulation.

  • M. Burg
  • Biology
    The American journal of physiology
  • 1995
Osmotic regulation of inositol and taurine uptake also involves increased expression of specific transporter genes, and GPC is unique in that its level rises in response to high urea, as well as hypertonicity.