Functional significance of cell volume regulatory mechanisms.

@article{Lang1998FunctionalSO,
  title={Functional significance of cell volume regulatory mechanisms.},
  author={Florian Lang and Gillian L. Busch and Markus Ritter and Harold V{\"o}lkl and Siegfried Waldegger and Erich Gulbins and Dieter H{\"a}ussinger},
  journal={Physiological reviews},
  year={1998},
  volume={78 1},
  pages={
          247-306
        }
}
To survive, cells have to avoid excessive alterations of cell volume that jeopardize structural integrity and constancy of intracellular milieu. The function of cellular proteins seems specifically sensitive to dilution and concentration, determining the extent of macromolecular crowding. Even at constant extracellular osmolarity, volume constancy of any mammalian cell is permanently challenged by transport of osmotically active substances across the cell membrane and formation or disappearance… 

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