Functional significance of a putative Sp1 transcription factor binding site in the survivin gene promoter

@article{Mityaev2008FunctionalSO,
  title={Functional significance of a putative Sp1 transcription factor binding site in the survivin gene promoter},
  author={Maxim Mityaev and Eugene P. Kopantzev and Anton Buzdin and Tatyana V. Vinogradova and E. D. Sverdlov},
  journal={Biochemistry (Moscow)},
  year={2008},
  volume={73},
  pages={1183-1191}
}
We sequenced 1500-bp genomic DNA regions upstream from the survivin gene (BIRC5). DNA was isolated from human placenta and tumors of patients with diagnosed squamous cancer of the lung that showed high-level BIRC5 gene expression. We have revealed four new promoter allelic variants differing in single nucleotide substitutions, one variant with two nucleotide substitutions, and a variant with a TAAA tetranucleotide insertion. All promoter variants displayed low activity in cells with… CONTINUE READING